Sameera is the youngest of the Reddy sisters; her older sister Meghna is an International model and Sushma is a VJ and actress. Sameera steeped into the glamour world with a Pankaj Udhas music video Ahista Ahista.

Sameera was signed by Sohail Khan for his actor debut Maine Dil Tujhko Diya in which Sameera played a shy college girl. Sameera was a complete revelation in Musafir in which she got transformed to a glam babe and sizzled on a couple of tracks. Sameera was also romantically linked to Sanjay Gupta and that made her part ways with her mentor. Sameera did mange to make an impression in Taxi No 9211.

Sameera is also the first Indian actress to have her mobile game called SamMission. Sameera won a lot of critical acclaim for her complete no make up role in Kaalpurush which established her as an actress with substance. Sameera has also acted in Naksha opposite Vivek Oberio and Ghulamiopposite Sunny Deol.